Biomedical Research and Therapy

Background: Cellular immunotherapies utilizing γδT cells hold immense promise for breast cancer as an MHC-independent approach; however, their clinical efficacy is profoundly dictated by the tumor microenvironment and systemic metabolic contexts. While cancer patients routinely consume widely available p...

Introduction: Despite therapeutic advancements, breast cancer remains a formidable clinical challenge, necessitating innovative therapeutic strategies that combine high specificity with enhanced potency. To address this need, we rationall...

Mesenchymal stem cell-derived peptides (MSC-DPs) are increasingly recognized as pivotal mediators of MSC paracrine activity, providing a strictly defined, cell-free alternative to conventional whole-cell therapies. Current evidence, largely derived from in vitro and preclinical animal models, indicates that thes...

Introduction: Telomerase is reactivated in approximately 90% of human malignancies, underscoring its potential as a cancer-selective therapeutic target with minimal off-target toxicity. Natural products derived from medicinal plants represent a promising and under...

Introduction: Nearly half of individuals diagnosed with acne vulgaris develop scarring. This study aimed to investigate the genetic associations between acne scarring and six selected gene variants (CYB5R1, IL1A, TLR4, FLG, SPINK5...